Hopper had an acting role in a radio soap opera, playing Portia Brent on the Blue Network's Brenthouse beginning in February 1939. She debuted as host of her own radio program, The Hedda Hopper Show, November 6, 1939. Sponsored by Sunkist, she was heard on CBS three times a week for 15 minutes until October 30, 1942. From October 2, 1944, to September 3, 1945, Armour Treet sponsored a once-a-week program. On September 10, 1945, she moved to ABC, still sponsored by Armour, for a weekly program that continued until June 3, 1946. Hopper moved back to CBS October 5, 1946, with a weekly 15-minute program, This Is Hollywood, sponsored by Procter & Gamble. It ran until June 28, 1947.