In 1952, Palade became a naturalized citizen of the United States. He worked at the Rockefeller Institute (1958–1973), and was a professor at Yale University Medical School (1973–1990), and University of California, San Diego (1990–2008). At UCSD, Palade was Professor of Medicine in Residence (Emeritus) in the Department of Cellular & Molecular Medicine, as well as a Dean for Scientific Affairs (Emeritus), in the School of Medicine at La Jolla, California.