She is known for co-writing and playing both the lead female and male counterpart roles in the film Liquid Sky. She also played a minor role of "Victoria" in the 1985 Susan Seidelman film Desperately Seeking Susan, the transvestite "Gwendoline" in Crocodile Dundee and starred in an episode of TV series Miami Vice. Carlisle also adapted and wrote a novel version of her cult, new wave film Liquid Sky.