William Howard Stein

William Howard Stein was born on June 25, 1911 in New York City, US, United States, is Biochemist. William Howard Stein was an American biochemist who was jointly awarded the ‘Nobel Prize in Chemistry’ in 1972 with American biochemists Stanford Moore and Christian B. Anfinsen. The contributory research work for which he received the award was concerned with structure of ribonuclease (RNase) and also for comprehending association of the ribonuclease molecule’s chemical structure with that of its catalytic activity. He collaborated with Moore to develop new procedures of chromatography, a process of separating a mixture, for applying to analyse amino acids and small peptides procured through protein hydrolysis. The first automatic amino-acid analyzer, which hugely aided in the study of amino acid sequences of proteins, was developed by them. They also used the new tool to make the first analysis of the complete chemical structure of the pancreatic enzyme ribonuclease. Stein spent his entire professional career at Rockefeller serving as Professor of Biochemistry first at the ‘Rockefeller Institute for Medical Research’ and thereafter at the ‘Rockefeller University’. He also remained visiting professor of many universities including ‘Harvard University’ and ‘University of Chicago’. He received several awards along with fellow biochemist Stanford Moore including the American Chemical Society Award in Chromatography and Electrophoresis in 1964; the ‘Linderstrom-Lang Medal’ from the ‘Carlsberg Research Center’ in 1972; and the ‘Richards Medal’ of the ‘American Chemical Society’ in 1972.
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