Born in Pittsburgh, Pennsylvania, Fowler moved with his family to Lima, Ohio, a steam railroad town, at the age of two. He graduated from the Ohio State University, where he was a member of the Tau Kappa Epsilon fraternity, and received a Ph.D. in nuclear physics at the California Institute of Technology. Although an experimental nuclear Physicist, Fowler's most famous paper was "Synthesis of the Elements in Stars", coauthored with Cambridge cosmologist Fred Hoyle and in collaboration with two young Cambridge astronomers, E. Margaret Burbidge and Geoffrey Burbidge. That 1957 paper in Reviews of Modern Physics categorized most nuclear processes for origin of all but the lightest chemical elements in stars. It is widely known as the BFH paper.