Ancona-born Lisi began her film career in her teens. Discovered in Rome by two Neapolitan producers, Antonio Ferrigno and Ettore Pesce, she debuted in La corda d'acciaio (The Steel Rope, 1953). Initially, she did musical films, like E Napoli canta (Naples Sings, 1953) and the successful Questa è la vita (Of Life and Love, 1954, with the popular Totò). Nonetheless, her beauty was more valued than her talent, as seen in Le diciottenni (Eighteen Year Olds) and Lo scapolo (The Bachelor) films of 1955. Yet she filled demanding roles, particularly in La donna del giorno (1956), Eva (1962), and the spectacle Romolo e Remo (1961).