On 29 September 2001, she gave birth to her first child, a girl named Lila, with production designer Louis Soubrier, whom she met on the set of A Single Girl in 1995. She was in a short-lived marriage with Iain Rogers, a film Director, from 2006 to 2007. From 2007 to 2015, she was in a relationship with actor Arie Elmaleh, whose brother Gad Elmaleh was her co-star in The Valet. Ledoyen and Arie Elmaleh have a son, Isaac, born in July 2010, and a daughter, Amalia, born in April 2014.