Watson-Johnson played Blue's love interest in the 1972 film Trick Baby. She was also a regular cast member of the 1985-86 situation comedy Foley Square as Denise Willums, the secretary for Alex Harrigan, played by the show's star, Margaret Colin. She played a small role on Sister, Sister as Lisa's (Jackée Harry) best friend Patrice, and as the mayor's secretary, Lucille Banks, on Carter Country. She also had a recurring role as "Birdie" on The Young and the Restless. In 2005, she appeared in the film Christmas with the Kranks. In addition, Watson-Johnson has made appearances in episodes of television shows as The Love Boat, Hill Street Blues, Married... with Children, L.A. Law, Suddenly Susan, Dharma & Greg, The X-Files, ER, Days of Our Lives, Malcolm in the Middle, CSI: Crime Scene Investigation, Desperate Housewives, Ghost Whisperer, Benson, The Big Bang Theory, Good Times, Dexter, Two and a Half Men, Southland, Criminal Minds, A.N.T. Farm, What's Happening!! and several other series.