His first confirmed role in film was in Crazy Joe in 1974, with the help of Richard Castellano. Sirico has played Gangsters in a number of films, including Goodfellas, Mob Queen, Mighty Aphrodite, Love and Money, Fingers, The One Man Jury, Defiance, The Last Fight, Innocent Blood, Bullets over Broadway, The Pick-up Artist, Gotti, The Search for One-eye Jimmy, Cop Land, Turn of Faith, Hello Again, and Mickey Blue Eyes.