He is best known for his film scores, particularly for the comedies State and Main, 13 Going on 30, Along Came Polly, The Devil Wears Prada, Fun with Dick and Jane, Idiocracy, You, Me and Dupree, Wet Hot American Summer, Marley & Me, Tropic Thunder, the Jay Roach film Dinner for Schmucks and was one of the composers for Diary of a Wimpy Kid. In 2012, Shapiro has composed his first animated film, The Pirates! Band of Misfits. He has also written other orchestral works.