Misner has guest starred on many TV series, including three of the series in the Law & Order franchise—Law & Order: Criminal Intent (2001/2005), Law & Order: Special Victims Unit (2002) and Law & Order (2006)—as well as both CSI: Crime Scene Investigation (2002) and CSI: Miami (2004). She had a dancing role in the 2002 film Chicago. Misner appeared as Theresa on Rescue Me in 2006 and 2007, and later as Gretchen Martin in the 2007 miniseries The Bronx Is Burning. She appeared in two episodes of the hit CBS procedural Without a Trace during the 2004–2005 television season. She portrayed Alison Humphrey in several 2007 episodes of The CW series Gossip Girl and Sergeant Burnett in New Amsterdam (2008). In 2010, she played the girlfriend of therapist Paul Weston in the series In Treatment. More recently, she has the role of Sandra Beeman in The Americans, and the recurring role of Simone Canning in The Good Wife.