In 2015, she played Graciela Arias in the film Los Crímenes del Mar del Norte, based on the true story of Goyo Cárdenas, the strangler of Tacuba. The following year, Espinosa played Mexican singer Lola Beltrán on Hasta Que Te Conocí, based on the life of Mexican Artist Juan Gabriel, for which she had to perform the track "Cucurrucucú Paloma", Beltrán's signature song. Espinosa co-produced, co-wrote, and starred in Los Bañistas, a film that had a limited release in Mexico (10 copies) in 2016. In the film, directed by Max Zunino, she plays Flavia, a young protester who gets involved with an older man, Juan Carlos Colombo. Espinosa's performance was met with positive reviews, such as the one written by Luis Fernando Galván of En Filme, stating that the Actress "effectively embodies the hope for social renewal from a convincing performance where she goes on a trip into a social space with the intention of finding her place in the world and helping others to do the same". Espinosa and Zunino re-teamed for Bruma, in which the Actress plays Martina, and according to John Hopewell of Variety, "follows a young woman (Espinosa) from Mexico's stifling upper middle-classes who, pregnant, escapes to Berlin and finds a kind of father figure and freedom in a Berlin club drag queen chanteuse and a final sense of her individual identity". The film was written by Espinosa and Zunino and won five awards at the 10th Works in Progress Guadalajara Festival. In 2016, it was announced by Variety magazine that Espinosa would join Mexican actors Demián Bichir and Diego Luna in the film The Black Minutes; in the same year, Espinosa played Rocío in the TV series Las Trece Esposas, produced by Blim and inspired by One Thousand and One Nights. Espinosa also had a voice role in the American animated film Kubo and the Two Strings (2016) and a role in La Gran Promesa, directed by Jorge Ramirez Suárez. Espinosa voiced the role of Miguel's mother in the animated film Coco (2017).