Rose was married to American actor Dylan McDermott in 1995 and they have two children, Colette (1996) and Charlotte Rose (2005). On September 27, 2007, People confirmed that Rose and McDermott had separated. Nearly eight months after the duo announced they had separated, the actor filed for divorce from his wife on May 21, 2008. Without either using lawyers, they peacefully separated as friends, with joint custody of their children. Their divorce was finalized on January 2, 2009. She resides with their daughters in Pacific Palisades, Los Angeles.