In early 1980, Greene had a role on the daytime drama Together (Southern Television/ITV), which began in January. She first appeared on Blue Peter after appearing in the BBC adaptation of Pamela Brown's The Swish of the Curtain, following which she was asked by the programme's Editor Biddy Baxter to be the replacement for the outgoing Tina Heath. At the time Greene was the youngest ever presenter of Blue Peter, aged 22 and within two weeks was filming in Cornwall for the show. The programme won BAFTA during Greene's 3-year tenure. After leaving Blue Peter, she presented Saturday Superstore with Mike Read, and subsequently co-presented Going Live! with Phillip Schofield. It was during her time on Going Live! that Greene won "Best Female on TV" SOS Award 3 years running and famously presided over the phone-in where Five Star were asked "why are you so fucking crap?". She then began to appear in television commercials for Nescafé coffee. Later, she fronted Channel 4's daytime antiques programme Collectors' Lot.