Sameera was born on 14 December 1980 in Rajahmundry, Andhra Pradesh to a Telugu family. Her father Chinta Poli (C. P.) Reddy is a businessman, while her mother Nakshatra, referred to as Niki by her daughters and in the media, was a microbiologist and worked with an NGO. She has two siblings, Meghna Reddy, a former VJ and supermodel, and Sushama Reddy, a Bollywood Actress and model, both elder to her. She did her schooling at Bombay Scottish School in Mahim, Mumbai and graduated from Sydenham College.