Reema made her directorial debut with Honeymoon Travels Pvt. Ltd. in 2006. Her next film, Talaash, was a suspense drama starring Aamir Khan, Rani Mukerji and Kareena Kapoor. In June 2016, she started filming Gold, a film about India's first Olympic gold medal after its independence. The film stars Akshay Kumar, Farhan Akhtar and Kunal Kapoor. The actors were trained in field hockey by former India captain Sandeep Singh.