As of 2006, she became part of the ensemble cast, co-starring alongside Sally Field, Calista Flockhart, Balthazar Getty and Matthew Rhys, of the dramatic series Brothers & Sisters, in which she portrays Sarah Walker, who inherits control of the family Business after her father's death. Griffiths received a 2007 Emmy nomination and a 2008 Emmy nomination for her work on the series. Griffiths received 2008 and 2009 Golden Globe nominations for her work on Brothers & Sisters. Additionally, she appeared as "Inez Scull" in the 2008 mini-series adaptation of Larry McMurtry's Comanche Moon.