Dratch has appeared in several movies, including Martin & Orloff, The Hebrew Hammer, Down with Love, Dickie Roberts: Former Child Star, Click, I Now Pronounce You Chuck and Larry, Spring Breakdown, and My Life in Ruins. She also has joined fellow SNL cast members on A.S.S.S.S.C.A.T.: Improv, which aired September 7, 2005, on the Bravo channel. Dratch also made television appearances on NBC's Third Watch and in a recurring role on The King of Queens (playing Denise, the on-off girlfriend of Spence, who worked in a bowling alley). Other television appearances include Monk, Frasier, Wizards of Waverly Place, 30 Rock, Aqua Teen Hunger Force, Inside Amy Schumer, Ugly Betty, and, more recently, in season five of The Middle. She also appeared online with Comedian Billy Eichner in a spoof of Jay-Z's and Alicia Keys's "Empire State of Mind", titled "Forest Hills State of Mind."