Breslin became a well-known philanthropist in both Cleveland, Ohio, and Baltimore, Maryland, after relocating to the city in 1995. She and husband Modell donated $5 million to the SEED School of Maryland, a public boarding school for disadvantaged junior high and high school students from around the state. They also donated $3.5 million to help restore the Lyric Opera House, and Breslin served on the boards of the Baltimore Symphony Orchestra and the Walters Art Museum, and also donated to the Baltimore Museum of Art.