Dudley earned her first major film role in the 2012 thriller Chernobyl Diaries. In 2013 she was cast in the 2015 demonic possession drama film The Vatican Tapes playing the possession victim Angela Holmes; Dudley's portrayal in the film earned positive notice from The New York Times reviewer Nicolas Rapold. Dudley's other notable movies include Chillerama, Paranormal Activity: The Ghost Dimension, Dumbbells, The Barber, and Dude Bro Party Massacre III.
Dudley's television roles include appearances on CSI: Miami and Arrested Development. In August 2015 she earned the regular role of Alice in Syfy's drama fantasy series The Magicians, replacing Sosie Bacon in the part. In mid 2016, Dudley guest-starred opposite David Duchovny in the second season of NBC's docudrama Aquarius.
