DeWulf has been seen in a number of box-office hits, including Ocean's Thirteen, and The Back-up Plan. She has starred opposite Matthew McConaughey as Melanie, the present ghost in Ghosts of Girlfriends Past and played opposite Jeremy Piven in The Goods: Live Hard, Sell Hard. in 2009. She starred in The Taqwacores which premiered at Sundance in 2010. She co-starred with Charlie Sheen in the TV series Anger Management, which premiered June 28, 2012 on FX and concluded in December 2014. In 2014, DeWulf won Best Actress at the Comedy Ninja Film and Screenplay Festival for her portrayal of a murderous temp in the independent film Coffee, Kill Boss. In 2014, DeWulf was ranked #93 in Maxim magazine's "Hot 100" for the second time (the first time being 2007) as one of the most desirable women on the planet according to the magazine's readers. In 2009, she was listed in the 'Top 30 under 30' for Nylon magazine. In addition, DeWulf has appeared in pictorials in Details, Men's Health, Zink, Giant, and Complex. In 2015, Dewulf joined the cast and currently stars in Hockey Wives, a reality series that follows wives and girlfriends of professional hockey players.