In 2011, her first release was Nandini Reddy's romantic comedy Ala Modalaindi, which was Nithya's maiden Telugu venture as well. The film opened to favourable reviews by critics and turned out to become a sleeper hit, while Nithya received critical praise for her performance. Idlebrain's Jeevi in his review cited that she "epitomized Nitya character with her fabulous performance", "looks beautiful in all kinds of dresses" and was "the best debut in recent years of Telugu cinema after Samantha in YMC", while another critic wrote that she was a "charming find" and "...quite the Genelia replacement that our cinema so badly needs right now." She eventually won the Nandi Award for Best Actress for her performance and received a nomination for Filmfare Award for Best Actress at the 59th Filmfare Awards South. Further more, she also sang two songs for the Soundtrack album of the film, tuned by Kalyani Malik. Nandini Reddy, later, went on to describe Nithya as "the discovery of the decade". Following Ala Modalaindi, she starred in Santosh Sivan's historical fiction Urumi as part of an ensemble cast. She portrayed a Chirakkal Princess named Bala, playing the love interest of Prabhu Deva's character, which gained positive remarks, with a Sify review claiming that she "looks pretty and is a scene stealer". Nithya quoted that much of her character was based on "Santosh's perception of who I am", with Sivan stating that he had written that role for her and that only she could play it. She received a nomination for Filmfare Award for Best Supporting Actress at the 59th Filmfare Awards South She next appeared in ad-filmmaker Jayendra's bilingual venture 180/Nootrenbadhu, made and released in Tamil and Telugu, in which she played a photo Journalist named Vidhya. She described the character as "bubbly, full of life, nosey, wide-eyed and innocent in life" and to be similar to herself. Later the year, she was seen in Sibi Malayil's Violin in Malayalam and the Gautham Menon-produced Veppam in Tamil.