Hollister was elected Ohio's 60th Lieutenant Governor in 1994 to replace incumbent lieutenant governor Mike DeWine, who was elected to the U.S. Senate. Hollister would oversee several State and Local Government Commissions. These included the Governor's Office of Appalachia, the Governor's Workforce Development Board, the Ohio Department of Agriculture, the Ohio Bureau of Employment Services, the Ohio School-to-Work Initiative, the Office of Housing and Community Partnership, the Ohio Coal Development Office, and the Ohio Farmland Preservation Task Force.