Hughes has also appeared in numerous television movies. He has been a series regular, recurring character or guest star on many television series. He played Aaron Bailey on Full House from 1990 to 1995. Other appearances have been in Baywatch (1989), Sister Kate (1989–90), Beverly Hills, 90210 (1991), Melrose Place (1992), Touched by an Angel (1994), and The Nanny (1994). Hughes received an Emmy Award certificate for his participation as the voice of Tommy in the number-one-rated Fox animated television series Life with Louie (1995). His other voice-over credits include twin babies, Sly and Witt, in the feature film Baby Geniuses (1999).