Brandon starred in the TV series Dempsey and Makepeace and Dinotopia, the movies Quattro mosche di velluto grigio (1971), F.M. (1978), A Vacation In Hell (1979) and A Change of Seasons (1980), and the plays Does a Tiger Wear a Necktie? and Jerry Springer - The Opera. Since moving to the UK, Brandon has worked in TV on such shows as The Bill, Trial and Retribution, and Dead Man Weds. He also played the title role in the musical Jerry Springer: The Opera for over a year in the National Theatre and after its transfer into the West End. Brandon starred in Singin' in the Rain in the summer of 2012. In 2004, he portrayed Nobel Prize winner Arno Penzias in the BBC TV movie Hawking about Physicist Stephen Hawking's early career at the University of Cambridge and was the US narrator of Thomas & Friends. In February 2008 he began his talk radio show on City Talk, a new local radio station in Liverpool. In 2008 he appeared in the Series 4 finale of the BBC's Doctor Who, as General Sanchez, a UNIT officer. Also in 2008 he appeared in the television series Bones, as Roger Frampton, an American millionaire.