In 1752, he married Abigail Burr of Fairfield, Connecticut, however, she died the following year. In 1757, he was married again to Mary Osborne. He migrated to South Carolina and established himself as a physician at Dorchester, South Carolina, near Charleston, a community settled by Congregationalist migrants from Dorchester, Massachusetts decades earlier. When these settlers moved to the Midway District – now Liberty County – in Georgia, Hall accompanied them. Hall soon became one of the leading citizens of the newly founded town, Sunbury.