She made other appearances on The Waltons, playing Olivia's Aunt Kate who consoles Olivia through her ordeal with menopause, The Alfred Hitchcock Hour, Bonanza, Gunsmoke, "Kojak", Hawaii Five-O, Ironside, Columbo, Quincy, M.E., Rhoda, Murder, She Wrote, The Streets of San Francisco, Family Affair as Aunt Fran, who leaves Buffy (Anissa Jones) in the care of Uncle Bill (Brian Keith) in the show's first episode, Designing Women (as Perky, the mother of Julia and Suzanne Sugarbaker), The X-Files, and The Invaders in the 1967 episode "Genesis". Latham's character was the first to learn the real circumstances of Dr. Richard Kimble's wife's death in the final episode of The Fugitive (1967). She was a regular in the cast of the short-lived 1976 CBS series Sara. She also appear in the series, Family Affair, playing the children’s Aunt Fran from Terra Hute