Ferrigno married Susan Groff in 1978, divorcing a year later. On May 3, 1980, he married psychotherapist Carla Green, who then also began serving as his manager; she later became a personal trainer. They have three children, Shanna, born 1981; Louis, Jr., born 1984; and Brent, born 1990. Shanna has a recurring role as Nurse Janice in Days of Our Lives, and appeared in the NBC series Windfall, as well as the television movie Within, and in 2005 she appeared in the E! reality television series, Filthy Rich: Cattle Drive. Louis, Jr. was a linebacker for the University of Southern California Trojans football team.