He appeared in three films since 2000: Hotaru (ホタル, The Firefly) in May 2001, Riding Alone for Thousands of Miles, by Chinese Director Zhang Yimou, in late December 2005, and Yasuo Furuhata's Anata e (Dearest) in late August 2012, after a six-year hiatus. He died of lymphoma on November 10, 2014. Shintaro Ishihara described him as "the last big star (in Japan)." A huge number of Chinese internet users expressed their sympathies and condolences, including many celebrities in the Chinese movie industry. The spokesman of China's Ministry of Foreign Affairs Hong Lei said that Takakura made significant contributions to the cultural exchange between China and Japan.