Reinders played the role of Glinda in the 2005 Chicago production of Wicked, alongside Ana Gasteyer as Elphaba; for this role, she received a Joseph Jefferson Award nomination for Best Actress in a Principal Role. She and Gasteyer finished their runs in the Chicago company on January 22, 2006. On May 30, 2006 she replaced Megan Hilty as Glinda in the Broadway production. While playing this role she performed "Popular" in a Daily Double about Wicked on an all-celebrity episode of Jeopardy!. TV personality Nancy Grace gave the correct question. She ended her run on January 7, 2007 along with former Chicago co-star, Ana Gasteyer.