She began acting in 1996 with the TV movie Kiss & Tell. After, Nathanson has done several television series and television movies such as Beverly Hills, 90210 (1996-1997), Soldier of Fortune, Inc.. (1998-1999), The Zeta Project (2001-2003) and Spider-Man: The New Animated Series. Since 2004, she is also often heard in video games as voices of different characters.