In 2012, Reyes was cast as series regular Zoila Diaz, the senior maid, in the ABC comedy-drama pilot Devious Maids, created by Marc Cherry. On May 14, 2012, the series was not picked up by ABC, but on June 22, 2012, Lifetime ordered a run of thirteen-episodes. The series premiered June 23, 2013. The Devious Maids finale episode aired on August 8, 2016. After two weeks following show' cancellation, Reyes was cast opposite Niecy Nash in the TNT crime comedy-drama, Claws.The series premiered on June 11, 2017.