McGuire was born in 1987 and brought up in the town of Warwick in Warwickshire.
McGuire has made cameo appearances in a number of BBC sitcoms and drama series and was a cast member in the 2011 BBC Two series The Hour. He also starred as assistant to Stephen Fry's character in the comedy series The Bleak Old Shop of Stuff, a parody of Charles Dickens' works..
In May 2016 McGuire is appearing the "comedy/drama series" as the role of Nunney in new BBC drama Love, Nina alongside Faye Marsay and Helena Bonham Carter.
