John McIntire was born in Spokane, Washington and was of Irish descent. He grew up around ranchers, an experience that would later inspire his performances in dozens of film and television westerns. A graduate of the University of Southern California, McIntire began acting in radio on Tarzan and the Diamond of Asher, where he met his Future wife, Jeanette Nolan. McIntire worked on many episodes of Suspense from the early 1940s. He was the narrator for the radio program The March of Time. He was active in the theatre, before he embarked on a lengthy film and television career as a character actor. He was already 40 when he made his big-screen debut in 1947, but went on to appear in films, often portraying police chiefs, judges, eccentric loners or other western characters.