Prescott was born in Washington, D.C., then adopted and raised in Hartsville, South Carolina. She is best known for her role as Jacqui in Season 1 of the television series The Walking Dead, which premiered on AMC in 2010. Prescott, a resident of Winston-Salem, North Carolina, divides her time between that city and Los Angeles. Prescott was originally cast for just two episodes of the premiere season of The Walking Dead. However, her character, Jacqui, was then written into the series cast of the season as well. Prescott reprises her role as Jacqui in the Season 3 episode "Hounded", as one of the voices that speaks to Rick on the phone.