Lano made her debut in the 1997 film Shrieker. She also made appearances in Blade, S.W.A.T., Ghost Rock, Stealing Candy and Fashionably L.A., as well guest starring in the TV series The Shield, Xena: Warrior Princess and NCIS. In 2004 she voiced the character of Xenia Onatopp in the video game GoldenEye: Rogue Agent.