Immediately following the cancellation of Stargate Universe, Spence joined some other of the show's cast (including Michael Dopud) in a pilot of the new show Echoes, produced by Stargate's Mark Savela and Ken Kabatoff. In 2012, Spence had roles in episodes of three network television shows, The Killing, Alcatraz and Supernatural. Spence had a recurring role in the science fiction television series Continuum, as Detective Betty Robertson, which aired from May 2012 - October 2015. In 2013, Spence had a featured role in award-winning film “Down River”, which was written and directed by her husband Ben Ratner. Spence was born and raised in Toronto, Ontario, to a British father and third-generation Japanese Canadian mother. She currently resides in Vancouver, British Columbia.