Collison is best known to TV audiences as Horace Bing, the bumbling telegraph operator, on CBS's long-running series Dr. Quinn, Medicine Woman. His numerous other television appearances have included guest-starring roles on Monk, HBO's Carnivàle, Star Trek: The Next Generation, Criminal Minds, Seventh Heaven, Matlock, NYPD Blue, Hill Street Blues, Stargate Atlantis and Good Luck Charlie. In 2016 he appeared in the sixth season of the anthological series American Horror Story (Roanoke). He is a recurring voice actor by voicing Grandpa Goodman in the Adult Swim original Mr. Pickles.