In 2006, starred alongside Kevin Zegers and Samaire Armstrong in the 2006 romantic comedy It's a Boy/Girl Thing, in which she played the character Chanel. In 2009, she appeared in The Trotsky as Leon Trotsky's love interest Alexandra. In 2010, she starred in the Canadian indie film, Good Neighbours. Hampshire has also done voice-acting, voicing the character Misery on the animated series Ruby Gloom, Diana Barry in Anne of Green Gables: The Animated Series, Chloe Crashman in Carl Squared, Starr in 6Teen, and Alyson Malitski in Braceface.