Stamatopoulos worked as a creative consultant and contributing Writer on the first season of Tom Goes to the Mayor, with Tim & Eric and Bob Odenkirk. He also provided the voice of Drinky Crow on The Drinky Crow Show, which aired for one season on Adult Swim. His stop motion animated series Moral Orel premiered on Adult Swim on Christmas 2005 and aired for three seasons, airing its final episode in December 2008; a follow-up special aired in 2012. Following Moral Orel, Stamatopoulos created Mary Shelley's Frankenhole, a stop motion series, for Adult Swim. It ran for two seasons from 2010 to 2012.