Cameron is married to Samantha Gwendoline Sheffield, the daughter of Sir Reginald Sheffield, 8th Baronet and Annabel Lucy Veronica Jones (now Viscountess Astor). A Marlborough College school friend of Cameron's sister Clare, Samantha accepted Clare's invitation to accompany the Cameron family on holiday in Tuscany, Italy, after graduating from Bristol School of Creative Arts. It was then David and Samantha's romance started. They were married on 1 June 1996 at the Church of St Augustine of Canterbury, East Hendred, Oxfordshire, five years before Cameron was elected to parliament. The Camerons have had four children. Their first, Ivan Reginald Ian, was born on 8 April 2002 in Hammersmith and Fulham, London, with a rare combination of cerebral palsy and a form of severe epilepsy called Ohtahara syndrome, requiring round-the-clock care. Recalling the receipt of this news, Cameron was quoted as saying: "The news hits you like a freight train ... You are depressed for a while because you are grieving for the difference between your hopes and the reality. But then you get over that, because he's wonderful." Ivan was cared for at the specialist NHS Cheyne Day Centre in West London, which closed shortly after he left it. Ivan died at St Mary's Hospital, Paddington, London, on 25 February 2009, aged six. The Camerons have two daughters, Nancy Gwen (born 2004) and Florence Rose Endellion (born 2010), and a son, Arthur Elwen (born 2006). Cameron took paternity leave when Arthur was born, and this decision received broad coverage. It was also stated that Cameron would be taking paternity leave after his second daughter was born. She was born on 24 August 2010, three weeks prematurely, while the family was on holiday in Cornwall. Her third given name, Endellion, is taken from the village of St Endellion near where the Camerons were holidaying.