Muse moved to Chicago for a while, and then moved to Hollywood and performed in Hearts in Dixie (1929), the first all-black movie. For the next fifty years, he worked regularly in minor and major roles. While with the Lafayette Players, Muse worked under the management of Producer Robert Levy on productions that helped black actors to gain prominence and respect. In regards to the Lafayette Theatre's staging of Dr. Jekyll and Mr. Hyde, Muse said the play was relevant to black actors and audiences "because, in a way, it was every black man's story. Black men too have been split creatures inhabiting one body.". Muse appeared as an opera singer, minstrel show performer, vaudeville and Broadway actor; he also wrote songs, plays, and sketches. In 1943, he became the first African American Broadway Director with Run Little Chillun.