Nesbitt's first Hollywood film was Three Coins in the Fountain (1954), in which she played the character role of La Principessa. This was followed that same year by Black Widow, in which she played Lucia Colletti. She was Cary Grant's Grandmother Janou in 1957's An Affair to Remember (though she was, in fact, only 16 years older than Grant) and, the following year, was part of the ensemble cast of Separate Tables. She also appeared in The Parent Trap (1961), and Promise Her Anything (1965).