Amte married Indu Ghuleshastri (later called Sadhanatai Amte). She participated in her husband's social work with equal dedication. Their two sons, Vikas Amte and Prakash Amte, and daughters-in-law, Mandakini and Bharati, are doctors. All four dedicated their lives to social work and causes similar to those of the senior Amte. Prakash and his wife Mandakini run a school and a hospital at Hemalkasa village in the underprivileged district of Gadchiroli in Maharashtra among the Madia Gond tribe, as well as an orphanage for injured wild animals, including a lion and some leopards. She left her governmental medical job and moved to Hemalkasa to start the projects after they married. Their two sons, Dr. Digant and Aniket also dedicated their lives to the same causes. In 2008, Prakash and Mandakini received the Magsaysay Award for Community Leadership.