In 1948, Spanos married Faye Papafaklis. They have four adult children: Dean Spanos, the Chargers' team president; Michael Spanos, the Chargers' executive vice president; Alexis Spanos Ruhl, a vice President of A.G. Spanos Companies; and Dea Spanos Berberian, a vice President of A.G. Spanos Companies. The Spanoses reside in Stockton, California. Spanos also owns property in Las Vegas, Nevada. Spanos had a seven-way heart bypass in 2000, and has had surgery and undergone chemotherapy for colon cancer. After his heart bypass at Sacramento Mercy General Hospital, Spanos donated $10 million to the hospital to sponsor the construction of its new state-of-the-art heart center.